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目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并高脂血症的临床效果。方法选取大同市第五人民医院2015年3月—2016年1月收治的高血压合并高脂血症患者138例,按照随机数字表法分为试验组(n=65)和对照组(n=73)。试验组患者给予氨氯地平阿托伐他汀钙片治疗,对照组患者给予氨氯地平治疗,治疗前后分别检测并比较两组患者的收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及不良反应发生情况。结果治疗前,两组患者SBP、DBP、TC、TG、HDL-C、LDL-C比较,差异无统计学意义(P>0.05)。治疗后,两组患者SBP、DBP、TC、TG、LDL-C均低于治疗前,HDL-C高于治疗前,差异有统计学意义(P<0.05);且试验组SBP、DBP、TC、TG、LDL-C均低于对照组,HDL-C高于对照组,差异有统计学意义(P<0.05)。试验组血压、血脂治疗总有效率均高于对照组,差异有统计学意义(P<0.05)。且两组患者不良反应轻微。结论氨氯地平阿托伐他汀钙片治疗高血压合并高脂血症疗效确切,安全性好。
Objective To investigate the clinical efficacy of amlodipine atorvastatin calcium in the treatment of hypertension and hyperlipidemia. Methods 138 patients with hypertension and hyperlipidemia admitted to the Fifth People’s Hospital of Datong City from March 2015 to January 2016 were randomly divided into experimental group (n = 65) and control group (n = 73). Patients in the test group were treated with amlodipine atorvastatin calcium tablets, and patients in the control group were given amlodipine. Before and after treatment, the patients were tested for SBP, DBP, TC ), Triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and adverse reactions. Results Before treatment, there was no significant difference in SBP, DBP, TC, TG, HDL-C and LDL-C between the two groups (P> 0.05). After treatment, SBP, DBP, TC, TG and LDL-C in both groups were significantly lower than those before treatment and HDL-C was higher than before treatment (P <0.05) , TG, LDL-C were lower than the control group, HDL-C was higher than the control group, the difference was statistically significant (P <0.05). The total effective rate of blood pressure and blood lipids in the experimental group was higher than that in the control group, with significant difference (P <0.05). Adverse reactions were mild in both groups. Conclusion Amlodipine atorvastatin calcium treatment of hypertension combined with hyperlipidemia effective and safe.