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本文就近年来对单抗在恶性血液病中诱导肿瘤细胞凋亡与分化机制研究的最新进展作一综述。1单克隆抗体通过多个途径诱导肿瘤细胞的凋亡1.1直接激活细胞凋亡信号引起细胞凋亡1.1.1单抗促使细胞表面抗原交联介导细胞凋亡目前应用于临床治疗恶性血液病的CD 20单抗(R itux im ab,美
In this paper, we review recent progress in the study of the mechanism of apoptosis and differentiation induced by monoclonal antibodies in malignant hematological diseases in recent years. 1 Monoclonal Antibodies Induces Apoptosis of Tumor Cells Via Multiple Pathways 1.1 Directly Activates Apoptosis Signals to Cause Apoptosis 1.1.1 Monoclonal Antigen Leads to Cross-linking of Cell Surface Antigens Apoptosis Currently Used in the Clinical Treatment of Hematologic Malignancies CD 20 mAb (R itux im ab, the United States