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在肾脏病、糖尿病、高血压、动脉粥样硬化病人和老年人中,造影剂致肾中毒危险性增加。腺苷脱氨酶结合蛋白(ABP)、肾小管酶类-丙氨酸氨肽酶(AAP)和r-谷酰基转移酶(GGT)、溶酶体酶-N-乙酰-B-D-氨基葡萄糖苷酶(NAG)被建议作为急性肾小管损伤的早期标志。作者研究了尿ABP排泄作为病人使用造影剂引起肾毒性的一种早期标志的效果。经静脉肾盂造影(IVP)的9例病人被分成离子剂(泛影酸盐)组(4例)和非离子剂(碘酞六醇)组5例。测定病人造影前和造影24小时后30 m l尿中ABP、AAP、GGT、NAG和血清肌酐的水平。结果显示,用ELISA测得ABP水平,离子剂造影组造影前和造影后分别为((?)±SEM)0.20±0.08
In nephrotic, diabetic, hypertensive, atherosclerotic patients and the elderly, the risk of contrast-induced nephrotoxicity increases. Adenosine deaminase binding protein (ABP), tubular enzyme-alanine aminopeptidase (AAP) and r-glutamyl transferase (GGT), lysosomal enzyme N-acetyl-BD-glucosaminide Enzyme (NAG) is suggested as an early marker of acute tubular injury. The authors studied the effect of urinary ABP excretion as an early marker of nephrotoxicity in patients using contrast media. Nine patients undergoing intravenous pyelography (IVP) were divided into two groups: ionotropic agent (ip) group (n = 4) and non-ionic agent (iptaxylol group) The levels of ABP, AAP, GGT, NAG and serum creatinine in urine before and 30 min after angiography were measured. The results showed that the level of ABP measured by ELISA was (± SEM) 0.20 ± 0.08 before and after angiography