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目的 探讨升压治疗对局灶性脑缺血的保护作用及治疗时间窗。方法 采用大鼠局灶性脑缺血再灌注模型 ,30只大鼠随即分为 6组 :对照组、缺血即刻升压、缺血 1h升压、缺血 2h升压、缺血 3h升压、缺血 4h升压。观察血脑屏障破坏程度、脑梗死体积的情况。结果 缺血后 3h、4h升压后脑梗死体积与对照组分别为 4 0 9.96± 79.34mm3 、4 13.13± 6 8.14mm3 、4 10 .8± 87.6 9mm3 无统计学差异 (P >0 .0 5 ) ,且血脑屏障破坏程度明显大于对照组。结论 缺血 3h再灌注时 ,升压时间窗不超过 2h。
Objective To investigate the protective effect of antihypertensive treatment on focal cerebral ischemia and the treatment time window. Methods The model of focal cerebral ischemia-reperfusion in rats was established. Thirty rats were randomly divided into 6 groups: control group, immediate booster of ischemia, step-up of 1 h of ischemia, step-up of 2 h of ischemia and step of 3 h of ischemia , 4h ischemia and step-up. Observe the degree of damage to the blood-brain barrier, the volume of cerebral infarction. Results There was no significant difference in the volume of cerebral infarction between the 3h and 4h after HI and the control group (40.96 ± 79.34mm3, 41.13 ± 6.181mm3, 4.108 ± 87.69mm3 respectively) (P> 0.05) , And the extent of damage to the blood-brain barrier was significantly greater than that of the control group. Conclusions During reperfusion at 3h after ischemia, the time window of step-up does not exceed 2h.