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目的研究CD4~+、CD8~+淋巴细胞在乳腺浸润性微乳头状癌中的表达与乳腺浸润性微乳头状癌预后的关系。方法收集78例浸润性微乳头状癌(IMPC)患者肿瘤组织,利用免疫组织化学双染技术检测肿瘤组织中浸润淋巴细胞CD4~+、CD8~+表达情况,分析其表达差异与临床病理学指标以及患者预后的关系。结果淋巴细胞中CD4~+、CD8~+的表达与组织学分级、肿瘤TNM分期、淋巴结转移、肿瘤复发相关(P<0.05);乳腺浸润性微乳头状癌中CD4~+、CD8~+淋巴细胞浸润越多,患者术后无病生存率也越高(P<0.05)。结论乳腺浸润性微乳头状癌中淋巴细胞CD4~+、CD8~+的表达不仅与临床病理学指标相关,也与患者的临床预后差密切相关,提示其可能是一个潜在判断乳腺浸润性微乳头状癌预后分子标志物。
Objective To study the relationship between the expression of CD4 ~ + and CD8 ~ + lymphocytes in breast invasive micro-papillary carcinoma and the prognosis of invasive breast micro-papillary carcinoma. Methods The tumor tissues of 78 patients with invasive micro-papillary carcinoma (IMPC) were collected. The expression of CD4 ~ + and CD8 ~ + in infiltrating lymphocytes was detected by immunohistochemical double staining technique. The expression differences and clinicopathological parameters were analyzed As well as the prognosis of patients. Results The expressions of CD4 ~ + and CD8 ~ + in lymphocytes were correlated with histological grade, TNM stage, lymph node metastasis and tumor recurrence (P <0.05) The more cells infiltrated, the higher the disease-free survival rate (P <0.05). Conclusion The expression of CD4 ~ + and CD8 ~ + in lymphocytes in invasive breast micro-papillary carcinoma is not only correlated with clinicopathological parameters, but also closely correlates with the clinical prognosis of patients. It suggests that it may be a potential diagnostic marker for invasive infiltration of micro-papilla Cancer prognosis molecular markers.