白癜风(Vitiligo)又称白斑病(Ieukoderma),是常见的局限性色素减退性皮肤病。由于病因复杂,难以治疗,故本病一直是皮肤疾患中的难症之一。为了搞清发病机制,寻求有效的治疗途径,很久以来科学工作者进行了大量的研究工作,并认为本病的发生与遗传、神经及外伤等等因素有关。近代随着边缘学科的崛起及其不断向各个领域渗透,许多研究者从生物化学的角度对白癜风的病理进行了较为广泛深入的研究,迄今已取得了进展。本文试就这方面的研究报道粗略地探讨一下白癜风的发病机理。目前一般认为,白癜风是由于皮肤中黑色素缺乏所致。黑色素是在体内酪氨酸酶等催化下,由酪氨酸经一系列生化过程合成的。因此,黑色素在体内的合成与白癜风患者局部皮肤色素缺乏之间的关系就成了许多研究者感兴 Vitiligo, also known as leukoplakia (Ieukoderma), is a common localized hypopigmentary dermatosis. Due to the complex etiology and difficulty in treatment, this disease has always been one of the difficulties in skin disorders. In order to find out the pathogenesis and seek effective treatment, scientists have carried out a large amount of research work for a long time, and think that the occurrence of the disease is related to factors such as heredity, nerves and trauma. In modern times, with the rise of marginal disciplines and their continuous penetration into various fields, many researchers have conducted extensive and in-depth studies on the pathology of vitiligo from the perspective of biochemistry. So far, progress has been made. This article tries to roughly discuss the pathogenesis of vitiligo in this research report. It is currently believed that vitiligo is caused by a lack of melanin in the skin. Melanin is synthesized from tyrosine via a series of biochemical processes catalyzed by tyrosinase in the body. Therefore, the relationship between the synthesis of melanin in vivo and the local skin pigment deficiency in patients with vitiligo has become a source of interest for many researchers.