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目的:探索支原体感染与女性不孕不育的关系。方法:选择2010年1月～2010年12月226例女性不孕不育患者,采集患者宫颈分泌物进行支原体培养,对阳性组进行药效试验,并选择敏感抗菌药进行治疗。结果:阳性组患者输卵管通畅者构成比为35.2%,显著低于阴性组(P<0.05);而输卵管通而不畅和输卵管堵塞构成比分别为22.9%和41.9%,显著高于阴性组(P<0.05)。阳性组不孕时间显著长于阴性组(P<0.05);且NK细胞比例显著高于阴性组(P<0.05)。交沙霉素耐药发生率最低,为1.0%。结论:支原体感染和女性不孕不育发病具有相关性,不同地区的支原体感染者药物敏感性存在差别,为获得理想的治疗效果,应依据药敏试验结果选择抗菌药物。
Objective: To explore the relationship between mycoplasma infection and female infertility. Methods: A total of 226 female infertility patients were selected from January 2010 to December 2010. Cervical secretions of patients were collected for mycoplasma culture. The positive group was tested for efficacy and the sensitive antibacterials were selected for treatment. Results: The constituent ratio of tubal patency in the positive group was 35.2%, which was significantly lower than that in the negative group (P <0.05), while the ratio of tubal patency and tubal blockage were 22.9% and 41.9% respectively, significantly higher than that in the negative group P <0.05). The infertility time of the positive group was significantly longer than that of the negative group (P <0.05), and the proportion of NK cells was significantly higher than that of the negative group (P <0.05). The lowest incidence of josamycin resistance was 1.0%. CONCLUSION: Mycoplasma infection is associated with the incidence of infertility in women. Mycoplasma infection varies in different areas. To obtain the desired therapeutic effect, antimicrobial agents should be selected based on the susceptibility test results.