论文部分内容阅读
目的初步探讨血清25-羟维生素D[25(OH)D]在良性阵发性位置性眩晕(BPPV)发生、复发中的作用。方法纳入2013年1月至2014年12月在上海交通大学医学院附属第九人民医院神经内科诊治的部分BPPV患者,根据1年随访结果,分为BPPV未复发组(n=207)及复发组(n=42),并将同期收治的其他眩晕病患者作为对照(n=43),比较3组患者血清25(OH)D水平的差异,并分析影响所有受试者血清25(OH)D水平的独立相关因素。结果与眩晕对照组相比,BPPV未复发组、复发组血清25(OH)D水平均下降(P均<0.01),而复发组与未复发组血清25(OH)D水平差异无统计学意义。BPPV复发组女性比例较其余两组略增高,但差异无统计学意义(P=0.073)。所有入组患者中女性血清25(OH)D水平低于男性[(18.7±7.5)ng/mL vs(21.7±8.3)ng/mL,P=0.002]。多因素逐层线性回归分析显示女性(β=-2.6,P=0.005)、BPPV(β=-5.5,P<0.001)是患者血清25(OH)D水平的独立影响因素。结论人血清25(OH)D水平存在性别差异,BPPV患者25(OH)D水平下降。
Objective To investigate the role of serum 25-hydroxyvitamin D [25 (OH) D] in the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV). Methods From January 2013 to December 2014, part of BPPV patients diagnosed and treated in Department of Neurology, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were divided into BPPV non-recurrence group (n = 207) and recurrence group (n = 42) .Serum 25 (OH) D levels were compared between the three groups (n = 43) and other vertigo patients treated at the same period. The serum levels of 25 (OH) D The level of independent relevant factors. Results Compared with dizziness control group, the serum levels of 25 (OH) D in BPPV group were significantly lower than those in control group (P <0.01), but there was no significant difference in serum 25 (OH) D level between BPPV group and non-recurrence group . The proportion of women with BPPV recurrence group was slightly higher than the other two groups, but the difference was not statistically significant (P = 0.073). Serum 25 (OH) D levels were lower in women than in men [(18.7 ± 7.5) ng / mL vs (21.7 ± 8.3) ng / mL, P = 0.002] in all enrolled patients. Multiple linear regression analysis showed that female (β = -2.6, P = 0.005), BPPV (β = -5.5, P <0.001) were independent influencing factors for serum 25 (OH) D levels in patients. Conclusions There is a gender difference in serum 25 (OH) D levels, and the level of 25 (OH) D in BPPV patients is decreased.