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目的 探讨重型肝炎(重肝)血清甲状腺素水平与肝损害程度关系及意义。方法 放免法测定33例重肝、39例急性肝炎及30例正常人血清甲状腺素水平。结果 重肝T_3、T_4、TSH水平显著低于另外两组,rT_3则增高;T_3、T_4与血浆白蛋白呈正相关,T_3、TSH与凝血酶原时间、rT_3与谷丙转氨酶呈负相关;重肝死亡者T_3、T_4、TSH低于存活者,rT_3则增高。结论 重肝病人甲状腺素水平可作为反映肝功能的敏感指标,对判断疾病严重程度、预后很有价值。
Objective To investigate the relationship between serum thyroxine level and severity of liver damage in severe hepatitis (severe liver) and its significance. Methods The levels of serum thyroxine in 33 cases of severe hepatitis, 39 cases of acute hepatitis and 30 normal individuals were determined by radioimmunoassay. Results The levels of T_3, T_4 and TSH in severe liver were significantly lower than those in the other two groups and rT_3 was increased. T_3 and T_4 were positively correlated with plasma albumin, T_3, TSH and prothrombin time, rT_3 and alanine aminotransferase were negatively correlated. Death T_3, T_4, TSH lower than those who survive, rT_3 increased. Conclusion The thyroxine level in patients with severe liver disease can be used as a sensitive indicator of liver function, which is of great value in judging the severity and prognosis of the disease.