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给小鼠静脉注射低分子量（＜１０￣４ｕ）硫酸葡聚糖（ＤＳ）１５ｍｇ／ｋｇ后外周血中白细胞、单个核细胞（ｍｏｎｏｎｕｃｌｅａｒｃｅｋ，ＭＮＣ）、ＣＦＵ－ＧＭ、ＢＦＵ－Ｅ和ＣＦＵ－Ｍｉｘ产率等指标出现时相性变化。给药后１ｈ开始升高，２ｈ达到高峰、分别为药前值的２．２、２．６、３．８、４．４和３．０倍，７ｈ时趋向正常。给药后２ｈ上述各类细胞在外周血中的含量随着ＤＳ的剂量增加而增加。白细胞、ＭＮＣ计数在ＤＳ１８０ｍｇ／ｋｇ时达到峰值，均为对照组的４倍。２４０ｍｇ／ｋ８时未见明显增加。不同剂量ＤＳ对各系祖细胞均有不同程度的动员作用，ＤＳ剂量１５－３０ｍｇ／ｋｇ效果最好，每升血中ＣＦＵ－ＧＭ、ＢＦＵ－Ｅ、ＣＦＵ－Ｍｉｘ的数量分别相当于对照组的５．０、１１．９和８．８倍。其峰值出现时间与白细胞、ＭＮＣ不同，表明ＤＳ对不同类型细胞的作用机制也不尽一致。经口给小鼠投以ＤＳ２４０和４８ｏｍｇ／ｋｇ后，未见外周血中白细胞、ＭＮＣ计数有显著性升高，提示对造血干细胞没有动员作用。
Peripheral blood leucocytes, mononuclearcells (MNCs), CFU-GM, BFU-E and CFU-Mix were administered to mice intravenously at a low molecular weight (<10-4u) dextran sulfate (DS) Rate and other indicators appear when the phase change. After 1h administration began to rise, 2h peak, respectively, before the value of 2.2,2.6,3.8,4.4 and 3.0 times, 7h to normal. 2h after administration of the above types of cells in the peripheral blood levels increased with the dose of DS increased. White blood cells, MNC count peak at DS180mg / kg, were 4 times the control group. 240mg / k8 no significant increase. Different doses of DS have different degrees of mobilization on all progenitor cells. DS dose 15-30mg / kg is the best, the number of CFU-GM, BFU-E and CFU-Mix per liter of blood is equivalent to that of control group 5.0, 11.9 and 8.8 times. The peak appearance time and white blood cells, MNC different, indicating that the mechanism of action of DS on different types of cells are not the same. Oral administration of DS240 and 48omg / kg to mice, no peripheral blood leukocytes, MNC count was significantly increased, suggesting no mobilization of hematopoietic stem cells.