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目的:探讨同型半胱氨酸(Hcy)、尿微量白蛋白(UmAlb)/肌酐(UCr)比值检测在糖尿病肾病早期诊断中的意义,为今后的临床工作提供思路。方法:以我院内分泌科住院部于2014年7月至2015年3月期间收治的150例Ⅱ型糖尿病患者作为本组研究的观察对象,按照其24h尿微量蛋白排泄率(UAER)水平将其分为正常尿组(NA组)、微量蛋白尿组(MA组)与大量蛋白尿组(DN组)各50例,同时选取此期间内在我院行健康体检的50例健康人员作为对照组,分别采集各组患者的空腹静脉血液样本进行Hcy、UmAlb/UCr检测,并对检测结果进行对比分析。结果:DN组的血清Hcy水平为(19.35±5.72)μmol/L,UmAlb/UCr为(373.27±42.67);均明显高于MA组、NA组与对照组,具有统计学意义,P<0.01。MA组的血清Hcy水平与UmAlb/UCr也明显高于NA组与对照组,具有统计学意义,P<0.01,NA组与对照组之间比较均明显差异,不具有统计学意义,P>0.05。结论:Hcy联合UmAlb/UCr检测对糖尿病肾病的早期诊断与病情监测均具有重要的临床应用价值。
Objective: To investigate the significance of the detection of homocysteine (Hcy) and urinary microalbumin (UmAlb) / creatinine (UCr) ratio in the early diagnosis of diabetic nephropathy, and to provide ideas for the future clinical work. Methods: A total of 150 type Ⅱ diabetic patients admitted to Department of Endocrinology, Hospital of Endocrinology from July 2014 to March 2015 were selected as observation subjects in this study and their urinary microalbuminuria (UAER) 50 cases of normal urine group (NA group), microalbuminuria group (MA group) and a large number of proteinuria group (DN group) were divided into two groups. At the same time, 50 healthy people in our hospital were selected as the control group, Fasting venous blood samples of each group were collected for Hcy, UmAlb / UCr detection, and comparative analysis of test results. Results: Serum Hcy level in DN group was (19.35 ± 5.72) μmol / L and UmAlb / UCr was (373.27 ± 42.67), respectively, which were significantly higher than those in MA group, NA group and control group (P <0.01). MA serum Hcy level and UmAlb / UCr were significantly higher than the NA group and the control group, with statistical significance, P <0.01, NA and control groups were significantly different, there was no statistical significance, P> 0.05 . Conclusion: Hcy combined with UmAlb / UCr detection has an important clinical value in early diagnosis and condition monitoring of diabetic nephropathy.