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To review the latest research development of the solid lipid nanoparticles (SLN) according to the recent relevant literatures. Each preparations of the SLN have advantages and disadvantages. Among the total preparations of the SLN, the high pressure homogenization (HPH) and the microemulsion technique are to praise highly. The drug incorporation and release profiles could be modified as adjustment of production parameters. The SLN is an excellent drug delivery system and has broad prospects in the pharmaceutical field.