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目的:对老年人心衰的评估意义和血浆NT-ProBNP的诊断价值进行探讨,对老年人心衰患者的NT-ProBNP(血浆氮末端脑钠素前体)水平进行测定。方法:从老年心力衰竭患者中选取220例,健康老年人对照组112例,分别对心脏彩超左室射血的分数值(LVEF)%和血浆NT-ProBNP浓度进行测定,同时分组进行比较分析。结果:与对照组的血浆NT-ProBNP水平相比,心衰组较高,两组的比较具有显著差异性(P<0.01);NYHA分级和血浆BNP水平之间呈正相关,血浆NT-ProBNP水平会随着心衰程度的加重而逐步增高;随着心衰程度的加重,左室射血的分数水平也会不断降低,两组间的比较具有统计学差异(P<0.05)。结论:对于老年心力衰竭的诊断及预后判断来说,血浆NT-ProBNP的测定有着重要的临床价值。
Objective: To evaluate the significance of heart failure in elderly patients and the diagnostic value of plasma NT-ProBNP to determine the level of NT-ProBNP (plasma N-terminal pro brain natriuretic peptide) in elderly patients with heart failure. Methods: 220 elderly patients with heart failure and 112 healthy control subjects were enrolled in this study. The left ventricular ejection fraction (LVEF) and plasma NT-ProBNP concentration were measured respectively. Results: Compared with the control group, the NT-ProBNP level in the HF group was significantly higher than that in the control group (P <0.01). There was a positive correlation between the NYHA classification and plasma BNP level. The plasma levels of NT-ProBNP With the severity of heart failure increasing gradually; with the severity of heart failure, left ventricular ejection fraction will continue to decline, the two groups were statistically significant differences (P <0.05). Conclusion: For the diagnosis and prognosis of senile heart failure, the determination of plasma NT-ProBNP has important clinical value.