论文部分内容阅读
目的:探讨乙肝感染者血清HBVDNA与HBV-M各模式的关系及二者的诊断价值。方法:578份血清采用荧光定量PCR检测HBVDNA,同时用放射免疫法检测HBV-M。结果:HBV-M各模式HBsAg阳性者中HBeAg阳性组HBVDNA阳性率(95.21%)及病毒载量最高,与HBeAg阴性组(阳性率50.87%)比较有统计学差异(P<0.01),HBeAg阴性组以低载量者居多,但高复制者仍有19.05%;HBsAg阴性组HBVDNA阳性率仍有3.28%,病毒量都为低载量。结论:HBV-M与HBVDNA相互结合,才能正确判断HBV感染状况。
Objective: To investigate the relationship between serum HBVDNA and HBV-M in patients with hepatitis B infection and their diagnostic value. Methods: 578 serum samples were detected by real-time quantitative PCR for HBV DNA and HBV-M by radioimmunoassay. Results: The HBVDNA positive rate (95.21%) and viral load of HBeAg positive group were the highest among HBsAg positive patients in HBV-M model group, with significant difference (P <0.01) with HBeAg negative group (50.87%), HBeAg negative The majority of patients with low load, but still high copy 19.05%; HBsAg negative HBVDNA positive rate of 3.28%, the virus load are low. Conclusion: HBV-M and HBVDNA combined with each other in order to correctly determine the status of HBV infection.