血清脂质向动脉内膜下浸润与沉积,引起巨噬细胞吞食脂质,纤维组织增生等一系列反应,形成斑块,向动脉管腔内隆起,使血管狭窄或完全堵塞。由于斑块中心部因营养不良而发生软化、崩溃,外观呈粥状,在此基础上进一步发生钙质沉着,逐渐使动脉管壁变硬,故称动脉粥样硬化。斑块可能发生溃破、出血、血栓形成等,堵塞血管,引起组织缺血性坏死。周身动脉均可发生动脉粥样硬化,但最常见于心 Serum lipid infiltration and deposition to the artery intima, causing macrophages phagocytosis of lipid, fibrosis and a series of reactions, the formation of plaques, bulging into the lumen of the arteries, the blood vessels narrow or completely blocked. As plaque center due to malnutrition and softening, collapse, the appearance of porridge-like appearance, on the basis of further calcium calm, and gradually hardening of the arterial wall, so called atherosclerosis. Plaque may be ulcerated, bleeding, thrombosis, blockage of blood vessels, causing tissue ischemic necrosis. Arterial atherosclerosis can occur throughout the body, but the most common in the heart