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[目的]分析河南省南阳市张仲景医院(2012-2016)中药制剂致过敏性休克特点及规律。[方法]使用回顾性分析方法,在河南省南阳市张仲景医院病案室选择2012-2016年中药制剂致过敏性休克病历。统计专业人员采用Excel2013统计软件建立数据库,分析年龄、性别、用药情况、不良反应、给药途径、休克发生时间、转归等。[结果]纳入81例中药制剂致过敏性休克,均存在不同程度血压下降,14例(17.3%)存在过敏史,13例(16.0%)不存在过敏史,54例(66.7%)不清楚。81例中7例合并用药,均为2种。引起过敏性休克涉及中药制剂包括20多种,排在前四位的是鱼腥草、参麦注射液、双黄连注射液、清开灵注射液。过敏性休克最短发生时间在2min内,最长11d。休克患者,58例静脉给药,12例肌肉注射,9例口服,2例外用。经过抢救,77例(95.0%)痊愈,2例(2.5%)出现多器官损害,2例(2.5%)死亡。[结论]中药制剂应用中需要严格执行临床用药规律,注意患者过敏史,密切观察患者用药后的表现,及时治疗改善预后。
[Objective] To analyze the characteristics and rules of anaphylactic shock induced by traditional Chinese medicine in Zhang Zhongjing Hospital of Nanyang City, Henan Province (2012-2016). [Methods] The retrospective analysis method was used to select medical record of allergic shock induced by traditional Chinese medicine in 2012-2000 in the case of Zhang Zhongjing Hospital, Nanyang City, Henan Province. Statistical professionals using Excel2013 statistical software to establish a database, analysis of age, gender, medication, adverse reactions, route of administration, shock time, outcome and so on. [Results] 81 cases of allergic shock were involved in the treatment. There was a decrease in blood pressure to varying degrees. There were 14 cases (17.3%) with allergy history, 13 cases (16.0%) had no history of allergy and 54 cases (66.7%) were not clear. Among 81 cases, 7 cases were combined with two kinds of drugs. Caused anaphylactic shock Involving traditional Chinese medicine preparations, including more than 20 kinds, the top four are Houttuynia, Shen Mai injection, Shuanghuanglian injection, Qing Kai Ling injection. The shortest occurrence of anaphylactic shock in 2min, the longest 11d. Shock patients, 58 intravenous administration, 12 cases of intramuscular injection, 9 cases of oral administration, 2 cases of external use. After rescue, 77 cases (95.0%) recovered, multiple organ damage occurred in 2 cases (2.5%), and 2 cases (2.5%) died. [Conclusion] The application of traditional Chinese medicine need to strictly enforce the rules of clinical medication, pay attention to the history of allergy patients, closely observe the performance of patients after treatment, timely treatment to improve prognosis.