论文部分内容阅读
目的应用电感耦合等离子体质谱(ICP-MS)技术建立药用胶囊壳中铬(Cr)元素的快速测定方法。方法样品经密闭微波消解后,以钪(45Sc)作为内标元素,用电感耦合等离子体质谱直接测定元素的含量,并将该方法和2010年版《中国药典》标准方法(石墨炉原子吸收分光光度法)进行方法学比较。结果 Cr元素的线性相关系数(r)为1.000 0,检出限为0.079μg·L-1,精密度和稳定性的相对标准偏差(RSD)均小于4%,高、中、低浓度的加标回收率均在96.77%～101.5%之间,标准物质茶叶(GBW 07605)和标准物质西红柿叶(SRM 1573a)的测定值都在标准值的范围内。方法学显示,本方法和2010年版《中国药典》标准方法之间具有良好的一致性。结论本方法快速、准确,可作为2010年版《中国药典》的补充方法。
Objective To establish a rapid method for the determination of chromium (Cr) in medicinal capsules by inductively coupled plasma mass spectrometry (ICP-MS). Methods After the sample was sealed and microwave digested with scandium (45Sc) as the internal standard element, the content of the element was determined by inductively coupled plasma mass spectrometry. The method was compared with the standard method of Chinese Pharmacopoeia 2010 (graphite furnace atomic absorption spectrometry Photometry method for methodological comparison. Results The linear correlation coefficient (r) of Cr element was 1.000 0 with the detection limit of 0.079 μg · L-1. The relative standard deviations (RSDs) of precision and stability were all less than 4% The standard recoveries ranged from 96.77% to 101.5%. The standard value of tea leaves (GBW 07605) and reference material of tomato leaves (SRM 1573a) were all within the standard values. Methodology shows that there is good agreement between this method and the standard version of the 2010 Chinese Pharmacopoeia. Conclusion This method is rapid and accurate and can be used as a supplement to the 2010 edition of “Chinese Pharmacopoeia”.