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目的 研究直肠癌中血管内皮生长因子 (VEGF)的表达与 p5 3基因之间的关系。 方法 采用免疫组化方法对 4 5例直肠癌标本中VEGF和 p5 3基因的表达进行检测。 结果 在直肠癌中VEGF的表达率为 6 6 .6 7% (30 / 45 ) ,p5 3的表达率为 5 1.11% (2 3/ 45 ) ;在VEGF表达较高的区域 ,p5 3的表达亦较强 ,二者之间具有相关性 (P <0 .0 5 ) ,且与直肠癌的淋巴结转移相关 (P <0 .0 5 )。结论 在直肠癌中 ,VEGF的表达与 p5 3基因的表达呈正相关 ,在直肠癌的转移中起重要作用
Objective To study the relationship between the expression of vascular endothelial growth factor (VEGF) and p5 3 gene in rectal cancer. Methods Immunohistochemistry was used to detect the expression of VEGF and p53 genes in 45 specimens of rectal cancer. Results The expression rate of VEGF in rectal cancer was 66.76% (30/45), while the expression rate of p5 3 was 5 1.11% (23/45). In the region of high VEGF expression, the expression of p5 3 (P <0.05), which was also correlated with lymph node metastasis of rectal cancer (P <0.05). Conclusion In rectal cancer, the expression of VEGF is positively correlated with the expression of p5 3 gene and plays an important role in the metastasis of rectal cancer