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一、药品说明书上的用药不合理现象碘解磷定注射液为胆硷酯酶复活剂,临床在抢救治疗有机磷农药中毒患者时常出现中毒症状的反复,这是因为合成乙酰胆硷的乙酰辅酶A主要来源于葡萄糖分解后的中间产物丙酮酸在线粒体内的氧化脱羧,故在处方时加入葡萄糖等于提供了合成乙酰胆硷的物质基础,可使机体内乙酰胆硷量暂时又回升,结果出现了临床中毒症状的反复。有报道用林格氏液与葡萄糖注射液各1000 ml,输入机体后分别进行测定比较,结果两者对胆硷酯酶活性的影响完全不同,林格氏液仅
First, the medication instructions on the irrational phenomenon Iodine phosphate solution for injection of cholinesterase Resurrant, clinical treatment of organophosphate pesticide poisoning patients often appear repeatedly symptoms of poisoning, which is due to the synthesis of acetylcholine acetylcholine A is mainly derived from the oxidative decarboxylation of pyruvate in the mitochondria after glucose decomposition. Therefore, adding glucose at the time of prescription provides the material basis for the synthesis of acetylcholine, which can temporarily increase the amount of acetylcholine in the body, resulting in the appearance of Repeated clinical symptoms of poisoning. It has been reported using Ringer’s solution and glucose injection of 1000 ml, were measured after the body were compared, the results of both the activity of cholinesterase completely different Ringer’s solution