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研制了高分子药物-可乐定阴离子丙烯酸树脂盐并在模拟胃和小肠pH的缓冲液中进行了高分子药物的溶解释放试验。结果表明其中某些试样能够在微碱性的缓冲液中缓慢溶解释放,可望达到减少用药量。降低副作用和延长药效的目的。
Developed a high molecular drug - clonidine anionic acrylic resin salt and simulated in the stomach and small intestine pH of the polymer drug dissolution release test. The results show that some of these samples can be slowly dissolved in slightly alkaline buffer release, is expected to reduce the dosage. Reduce side effects and extend the efficacy of the purpose.