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目的观察鲑鱼降钙素对绝经后骨质疏松症的作用。方法鲑鱼降钙素治疗组９２例，隔日肌注５０Ｕ，每日加服元素钙３００ｍｇ，单用钙剂治疗的对照组２３例，每日服元素钙３００ｍｇ。疗程６个月。结果用药组腰２～４椎骨密度分别升高９．３％，１０．６％和８．９％，髋部骨密度无改变，与此同时，血骨钙素明显升高，尿羟脯氨酸／肌酐比值明显降低。对照组用药前后无明显改变。结论鲑鱼降钙素有改善绝经后骨质疏松病人腰椎骨密度作用，其机理与增加骨合成和降低骨吸收有关。
Objective To observe the effect of salmon calcitonin on postmenopausal osteoporosis. Methods 92 cases of salmon calcitonin treatment group, intramuscular injection of 50U every other day, add elemental calcium 300mg, calcium alone control group of 23 cases, the daily dose of elemental calcium 300mg. Course of 6 months. Results The lumbar 2 ~ 4 vertebrae density increased by 9.3%, 10.6% and 8.9% respectively in the lumbar vertebrae group and no change in the hip BMD. At the same time, the serum osteocalcin increased significantly, Acid / creatinine ratio decreased significantly. The control group before and after treatment did not change significantly. Conclusions Salmon calcitonin can improve the lumbar spine BMD in postmenopausal osteoporosis patients. Its mechanism is related to increased bone synthesis and decreased bone resorption.