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目的 研究 2型糖尿病病人血清肿瘤坏死因子 α(TNF α)水平变化及与胰岛素抵抗 (IR)的关系。方法 采用氧化酶法、放免法和酶联免疫法分别测定 3 8例 2型糖尿病病人 (A组 )、2 1例正常健康人 (B组 )的空腹血糖 (FBG)、空腹胰岛素 (FINS)及血清TNF α值 ,并计算胰岛素敏感指数 (ISI)。结果 A组FBG、FINS、TNF α水平较B组显著增高 ,而ISI较B组显著降低。结论 2型糖尿病病人TNF α水平增高 ,且与胰岛素抵抗相关 ,可能参与 2型糖尿病的发生和发展
Objective To study the changes of serum tumor necrosis factor α (TNF α) levels and the relationship with insulin resistance (IR) in type 2 diabetic patients. Methods The levels of fasting blood glucose (FBG), fasting insulin (FINS) and fasting insulin (FINS) in 38 patients with type 2 diabetes mellitus (A group) and 21 normal controls (B group) Serum TNFα values were calculated and insulin sensitivity index (ISI) calculated. Results The levels of FBG, FINS and TNFα in group A were significantly higher than those in group B, while those in group A were significantly lower than those in group B. Conclusions Patients with type 2 diabetes have elevated levels of TNFα and are associated with insulin resistance, which may be involved in the development and progression of type 2 diabetes