前列腺增生症是中老年男性的常见病,发病率随年龄递增。随着我国人均寿命的延长,老龄人口的增多,研究抗前列腺增生药物已引起广泛注意。目前国内的研究多数采用激素法,亦有用老年前列腺增生犬。前者给小鼠或大鼠注射雄激素(丙酸睾丸酮)引起外源性前列腺增生,其优点是简便迅速,适宜药物筛选,但与人类疾病的相关性较小;后者是选择有自发性前列腺增生的老龄犬观察药物疗效。迄今证明在哺乳类动物中只有老龄犬和人可发生自发性的前列腺增生,发病率 Prostatic hyperplasia is a common disease in middle-aged men, the incidence increases with age. With the extension of average life expectancy in our country, the population of aging population increases. Research on anti-hyperplasia drugs has drawn extensive attention. At present, the majority of domestic research using hormone therapy, but also useful for older BPH dogs. The former to mice or rats androgen injection (testosterone propionate) caused by exogenous prostatic hyperplasia, its advantage is simple and rapid, suitable for drug screening, but less relevant to human disease; the latter is the choice of spontaneous prostate Hyperplastic senile dogs observed drug efficacy. So far, it has been demonstrated that only dogs and humans with aging can develop spontaneous BPH in mammals. The incidence rate