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目的:采用光学相干断层扫描血管成像(OCT-A)测量正常人中心凹无血管区(FAZ)的面积及中心凹相关指标，分析影响FAZ面积的因素。方法:横断面研究。将郑州市第二人民医院2015年12月至2016年5月53名志愿者纳入研究，其中男24人，女29人，年龄19～53(31.7±8.3)岁。每人均行各项有关眼科检查。采用Pearson相关性分析各因素与FAZ面积之间的关系。结果:FAZ的面积为0.13～0.57(0.35±0.11)mmn 2。在Pearson相关性分析中，中心凹两侧视网膜高峰处距离(CC)，中心凹一半深度处宽度(FWHW)及中心凹深度(FD)均与FAZ面积呈正相关，相关系数分别为(n r＝0.484，0.642，0.428；n P<0.001)。中心区视网膜厚度(CMT)、中心凹感光细胞层厚度(FPT)及中心凹血流密度(FBFD)均与FAZ面积呈负相关，相关系数分别为(n r＝0.408，n P＝0.002；n r＝0.393，n P＝0.004；n r＝0.876，n P<0.001)。而年龄、性别、屈光度和最厚处视网膜厚度(MaxRT)均与FAZ面积无相关性(n P＝0.467，0.967，0.334，0.735)。n 结论:FAZ的面积不受年龄、性别、屈光度及MaxRT的影响；而与中心凹的形态、FBFD及CMT有关。“,”Objective:To analyze the influence factors of the area of foveal avascular zone (FAZ) and related indexes of fovea measured with optical coherence tomography angiography (OCT-A) in normal subjects.Methods:This was a cross-sectional study.Fifty-three subjects from Dec.2015 to May 2016 in Zhengzhou Municipal Sceond People's Hospital were recruited in the study, including 24 males and 29 females, aged 19-53 years, with an average of (31.7±8.3)years.Each subject received related eye examination.The correlation between all the factors and FAZ were analyzed under Pearson’s correlation analysis.Results:The area of FAZ was 0.13-0.57 mmn 2, with an average of (0.35±0.11)mmn 2.In Pearson’s correlation analysis, FAZ area was positively correlated with crest to crest distance (CC) of foveal retina (n r=0.484, n P<0.001), full width half maximum(FWHW) (n r=0.642, n P<0.001), and foveal depth(FD) (n r=0.428, n P=0.001). The area of FAZ was negatively correlated with central macular thickness(CMT)(n r=0.408, n P=0.002), foveal photoreceptor thickness(FPT) (n r=0.393, n P=0.004) and fovea blood flow density (FBFD)(n r=0.876, n P=0.000). The area of FAZ was not related with age, gender, spherical refraction and maximum retinal thickness (MaxRT) (n P=0.467, 0.967, 0.334, 0.735).n Conclusion:The area of FAZ was not affected by age, gender, diopter and MaxRT , but related to the shape of fovea, FBFD and CMT.