论文部分内容阅读
对蛋白质(TD抗原)的免疫应答是从抗原提呈细胞(APC)向辅助性T细胞(TH)提呈抗原而起始的。APC担此重任与其Ia分子有重要关连。以往认为,Ia分子的主要功能是与细胞处理后的抗原(Ag)片段在细胞膜上结合,形成Ag-Ia复合体,供T_H双重识别。近来研究证明,Ag经胞内处理而获得与Ia相结合的性能,通过Ia与Ag的结合,创造出供T_H识别的抗原决定簇—表位,并保护该表位免受进一步的酶解,而将之运送,呈现于细胞膜上,供抗原特异性T_H识别。本文介绍Ia功能研究的新进展,以及有关抗原处理和提呈的新学说。
The immune response to proteins (TD antigens) is initiated by the presentation of antigens from antigen presenting cells (APCs) to helper T cells (TH). The responsibility of APC is important to its Ia molecule. In the past that, Ia molecule’s main function is to cell-treated antigen (Ag) fragments in the cell membrane binding, the formation of Ag-Ia complex for T_H double recognition. Recently, it has been demonstrated that Ag has the property of binding to Ia by intracellular processing. Through the combination of Ia and Ag, an antigenic determinant epitope recognized by T_H is created and the epitope is protected from further enzymolysis. The transport, presented in the cell membrane for antigen-specific T_H recognition. This article describes new advances in Ia functional research, as well as new doctrines of antigen handling and presentation.