Cotinine是人体吸入烟草烟雾中尼古丁后经肝脏时其吡咯烷环被氧化的主要代谢产物。它的生物半减期较尼古丁相对长,而且不受饮食因素影响,是判定烟草烟雾吸入量比较客观而又特异的实验室指际。而烟草烟雾的吸入量越大,受到的危害通常越大,引起肺癌的危险性增加。大量研究已证明,主动吸烟与肺 Cotinine is the main metabolite of oxidation of the pyrrolidine ring when the body inhales nicotine in tobacco smoke through the liver. Its biological half-life is relatively longer than nicotine, and it is not affected by dietary factors. It is an objective and specific laboratory indicator for determining tobacco smoke inhalation. The greater the amount of tobacco smoke inhaled, the greater the damage that would normally be incurred and the increased risk of lung cancer. Extensive research has proven that active smoking and lungs