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多年来,以5-氟尿嘧啶(5-Ｆｕ)为主的化疗方案是大肠癌唯一的化疗方法,其有效率为20%。近几年中出现了几种对大肠癌有效的新药,现简介如下。化疗药物ＣＰＴ-11 ＣＰＴ-11是喜树碱的水溶性半合成衍生物。通过使拓扑异构酶失活造成ＤＮＡ单链不可逆的断裂而导致细胞死亡。其毒性(
Over the years, 5-fluorouracil (5-Fu) -based chemotherapy is the only chemotherapy for colorectal cancer with an effective rate of 20%. In recent years there have been several new drugs effective for colorectal cancer, are as follows. Chemotherapy Drug CPT-11 CPT-11 is a water-soluble semisynthetic derivative of camptothecin. Inactivation of topoisomerases causes irreversible cleavage of the single-stranded DNA causing cell death. Its toxicity