目的 :考察鼻咽癌中差异表达的生长因子 细胞因子 ,推测鼻咽癌发生中可能存在的免疫机制。方法 :采用cDNA阵列杂交技术 ,同时对 98个己知与肿瘤相关的生长因子 细胞因子在鼻咽癌、正常鼻咽组织及其他几种头颈部鳞癌中的mRNA表达水平进行筛查 ,筛选出在鼻咽癌中差异表达的生长因子 细胞因子基因。结果 :在鼻咽癌中上调的基因包括 :早期生长应答蛋白 1,肝癌来源生长因子 ,白介素 1β ,血小板来源生长因子A链 ,干细胞因子 ,畸胎瘤来源生长因子 ,干扰素诱导肽、蛋白 ,干扰素调节因子及干扰素受体等 ;在鼻咽癌中下调的基因有 :TGF β 2等。 结论 :鼻咽癌细胞可能自分泌或促进分泌大量生长因子 ,鼻咽癌侵润淋巴细胞分泌的细胞因子主要为Th1细胞型。 Objective: To investigate differentially expressed growth factor cytokines in nasopharyngeal carcinoma and to speculate the possible immunological mechanism in the pathogenesis of nasopharyngeal carcinoma. Methods: The mRNA expression levels of 98 cytokines known to be related to tumor in nasopharyngeal carcinoma, normal nasopharyngeal tissues and several other head and neck squamous cell carcinomas were screened by cDNA array hybridization. The differentially expressed growth factor cytokine genes in nasopharyngeal carcinoma. Results: Genes upregulated in NPC include: early growth response protein 1, hepatocellular carcinoma - derived growth factor, interleukin - 1β, platelet - derived growth factor A chain, stem cell factor, teratoma - derived growth factor, interferon - inducible peptide, Interferon regulatory factors and interferon receptors, etc .; genes down-regulated in nasopharyngeal carcinoma: TGF β 2 and so on. CONCLUSIONS: Nasopharyngeal carcinoma cells may autocrine or promote the secretion of a large number of growth factors. The cytokines secreted by nasopharyngeal carcinoma infiltrating lymphocytes are mainly Th1 type.