使用外源性胰岛素替代治疗糖尿病已经有80多年的历史,从1996年第一种胰岛素类似物-赖脯胰岛素面世至今,胰岛素类似物已经逐渐展露其在临床应用中的广泛前景。1什么是胰岛素类似物人胰岛素是一种可溶性酸性蛋白,每个单体包括2条肽链(A链和B链)。A链含21个氨基酸残基,B链含30个氨 It has been more than 80 years since exogenous insulin replacement therapy was used to treat diabetes. Insulin analogs have gradually revealed their broad prospects in clinical application since the release of insulin lispro, the first insulin analogue in 1996. 1 What is insulin analog? Human insulin is a soluble acidic protein, each monomer includes two peptide chains (A chain and B chain). The A chain contains 21 amino acid residues and the B chain contains 30 ammonia