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目的探讨不同剂型甲硝唑治疗滴虫阴道炎患者的临床治疗效果。方法选取2010年3月至2013年3月中山市坦背医院收治的滴虫阴道炎患者80例为研究对象,按治疗方案不同分为对照组和观察组,每组40例。对照组患者口服甲硝唑片治疗,观察组患者采用甲硝唑栓剂局部给药治疗,比较两组患者实验室检查结果及临床治疗效果。结果观察组患者滴虫数清除率为90.0%,显著高于对照组的67.5%,差异有统计学意义(P<0.05);观察组患者总有效率为92.5%,显著高于对照组的75.0%,差异有统计学意义(P<0.05);对照组患者不良反应发生率为15.0%,观察组未发生不良反应,差异有统计学意义(P<0.05)。结论甲硝唑治疗滴虫阴道炎具有一定的疗效,与口服甲硝唑片相比,甲硝唑栓剂局部给药治疗滴虫阴道炎患者的临床疗效更为显著。
Objective To investigate the clinical effects of different dosage forms of metronidazole in the treatment of trichomoniasis vaginitis. Methods Totally 80 cases of trichomonas vaginitis admitted to Tanshun Hospital of Zhongshan City from March 2010 to March 2013 were selected as control group and 40 cases in each group according to different treatment regimen. The patients in the control group were treated with oral metronidazole tablets. The patients in the observation group were treated with metronidazole suppositories locally. The laboratory test results and clinical effects were compared between the two groups. Results The number of trichomonads in the observation group was 90.0%, significantly higher than 67.5% in the control group (P <0.05). The total effective rate in the observation group was 92.5%, which was significantly higher than that in the control group %, The difference was statistically significant (P <0.05). In the control group, the incidence of adverse reactions was 15.0%. No adverse reactions were observed in the observation group. The difference was statistically significant (P <0.05). Conclusion Metronidazole treatment of trichomonas vaginitis has a certain effect, compared with oral metronidazole tablets, metronidazole suppository topical administration of trichomonas vaginitis in patients with clinical efficacy is more significant.