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目的观察原发性高血压患者血压水平与血浆抵抗素的关系,探讨血浆抵抗素在原发性高血压病发病中的作用。方法96例根据血压水平的高低分为正常血压组(N)、1级高血压组(H1)、2级高血压组(H2)和3级高血压组(H3),检测各组人群的血胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)、空腹血糖(FBG)、胰岛素(Ins)和血浆抵抗素(Resistin),并计算胰岛素敏感指数(ISI)。结果与N组相比,H1组、H2组和H3组原发性高血压病患者血浆抵抗素明显升高(P<0.01);各组原发性高血压病患者血浆抵抗素水平明显不同(P<0.01),血浆抵抗素水平与血压水平成正相关(r=0.328,P<0.01),多元逐步回归分析显示,抵抗素是影响血压水平的独立危险因素(R2=0.085,P<0.01)。结论原发性高血压患者血浆中抵抗素升高,抵抗素在原发性高血压发病中起一定的作用。
Objective To observe the relationship between blood pressure and plasma resistin in patients with essential hypertension and to explore the role of plasma resistin in the pathogenesis of essential hypertension. Methods According to the level of blood pressure, 96 cases were divided into normal blood pressure group (N), first grade hypertension group (H1), second grade hypertension group (H2) and third grade hypertension group (H3) TC, TG, HDL and LDL, fasting blood glucose (FBG), insulin (Ins) and plasma resistin (Resistin) were calculated and insulin sensitivity Index (ISI). Results Compared with N group, the plasma resistin in patients with essential hypertension in H1, H2 and H3 groups was significantly increased (P <0.01); the levels of plasma resistin in patients with essential hypertension were significantly different (R = 0.328, P <0.01). The multivariate stepwise regression analysis showed that resistin was an independent risk factor affecting blood pressure (R2 = 0.085, P <0.01), and the level of plasma resistin was positively correlated with the level of blood pressure . Conclusion The plasma resistin in patients with essential hypertension is elevated, and resistin plays a role in the pathogenesis of essential hypertension.