论文部分内容阅读
糖尿病肾病是1型糖尿病的主要慢性并发症,研究发现缺乏C肽是糖尿病肾病发病的重要原因之一,生理剂量的C肽具有多种生物学功能,能激活细胞内多种信号途径。C肽通过调节肾小球出、入球动脉和调节细胞内信号,能减少糖尿病实验动物和1型糖尿患者的尿白蛋白排泄,抑制肾小球高滤过状态、肾小球系膜基质增生和基膜增厚,对肾脏具有明显的保护作用。
Diabetic nephropathy is one of the major chronic complications of type 1 diabetes. Studies have found that the lack of C-peptide is one of the important causes of diabetic nephropathy. Physiological doses of C-peptide have a variety of biological functions and can activate various intracellular signaling pathways. C-peptide can reduce urinary albumin excretion, inhibit glomerular hyperfiltration state, glomerular mesangial matrix proliferation by regulating the glomerular exit and entry of the artery and regulating intracellular signals And thickening of the basement membrane, the kidney has obvious protective effect.