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目的总结探讨纳洛酮对急性酒精中毒的临床疗效及经验。方法将76例酒精中毒患者随机分为两组,治疗组40例,对照组36例,两组均常规给予洗胃、补液、保护胃粘膜、制酸治疗。治疗组同时给予纳洛酮0.4mg静推,严重患者间隔30min可重复使用1次,随后给予10%GS250mL+纳洛酮0.8mg静滴。结果患者清醒时间纳洛酮治疗组明显短于常规治疗组,差异有显著性(P<0.05)。结论纳洛酮治疗急性酒精中毒疗效肯定、使用简单安全,值得临床推广使用。
Objective To summarize the clinical efficacy and experience of naloxone on acute alcoholism. Methods 76 patients with alcoholism were randomly divided into two groups, 40 cases in the treatment group and 36 cases in the control group. Both groups were routinely given gastric lavage, fluid replacement, gastric mucosa protection and acid-producing therapy. The treatment group was given naloxone 0.4mg at the same time, serious patients interval 30min can be reused 1 time, followed by 10% GS250mL + naloxone 0.8mg intravenous infusion. Results Patients in naloxone treatment group were significantly shorter than those in routine treatment group at awake time (P <0.05). Conclusion Naloxone treatment of acute alcohol poisoning certainly positive, simple and safe, it is worth to promote the use of clinical.