【摘 要】
：
目的在国内首次采用全身显像法测定153Sm-EDTMP(乙二胺四甲撑膦酸)骨摄取率并探讨骨摄取率与疗效之间的关系.方法骨转移癌伴疼痛患者66例,男32,女34,年龄34～71岁,平均54岁.在
【机 构】
：
四川大学华西医学核医学科,中国工程物理研究院
论文部分内容阅读
目的在国内首次采用全身显像法测定153Sm-EDTMP(乙二胺四甲撑膦酸)骨摄取率并探讨骨摄取率与疗效之间的关系.方法骨转移癌伴疼痛患者66例,男32,女34,年龄34～71岁,平均54岁.在接受153Sm-EDTMP治疗期间未进行化疗或放疗.使用Elscint双探头γ相机,于注射153Sm-EDTMP后10分和5小时,进行全身显像并测定骨摄取率.结果 66例患者全身显像法测定的骨摄取率范围在31.9%～86.6%之间,平均56.0%.其中显效组(17例,25.7%)的骨摄取率为52.4%～86.6%,68.7±9.7;有效组(24例,36.4%)的骨摄取率为43.7%～70.4%,58.3±7.7;稳定或无效组(25例,37.9%)的骨摄取率为31.9%～51.5%,41.0±6.2.统计学分析表明,显效组与有效组(t=4.258,P=0.001)、有效组与稳定或无效组之间的骨摄取率也存在显著性差异(t=8.48,P=0.001).结论在国内首次采用全身显像法测定153Sm-EDTMP骨摄取率并前瞻性地计算153Sm-EDTMP安全而有效的个体化给药剂量;初步观察到骨摄取率与疗效之间的关系,即153Sm-EDTMP骨摄取率高的患者,其总体疗效好于骨摄取率低的患者.
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