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1例29岁女性患者因拔牙术后防治口腔感染服用甲硝唑0.4 g,3次/d。第2天出现舌苔变黑伴舌面溃烂,停药并用口腔溃疡散涂患处。第3天,黑色舌苔逐渐呈块状脱落,伴有疼痛感。第4天黑色舌苔完全脱落,溃烂面基本愈合。间隔2 d后患者因牙周肿痛再次自行服用甲硝唑0.4 g,2次/d。用药第2天再次出现舌苔变色。停用甲硝唑,改为口服阿莫西林0.5 g,3次/d,并给予氯芬待因止痛。2 d后患者舌面恢复正常。
A 29-year-old female patient received metronidazole 0.4 g, 3 times / d after dental extraction for prevention and treatment of oral infections. On the second day, the tongue became black with ulceration of the tongue surface, and the drug was stopped and the affected area spread with oral ulcers. The third day, the black tongue gradually lump off, accompanied by pain. Day 4 black tongue completely off, ulceration basically healed. After an interval of 2 d patients with periodontal swelling due to metronidazole 0.4 g, 2 times / d. The second day after treatment, the tongue discoloration occurred. Metronidazole was discontinued, changed to oral amoxicillin 0.5 g, 3 times / d, and given chlorpheniramine for pain relief. The patient’s tongue returned to normal after 2 days.