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严重充血性心力衰竭(CHF)患者,常突然死于室性心律失常。但因多数抗心律失常药有不良反应特别是负性肌力作用,而不能常规应用。作者采取随机对照平行式双盲研究,观察了血管紧张素转化酶(ACE)抑制剂Enalapril治疗CHF前及治疗后12周心律失常的变化。研究对象为20例慢性CHF(心功能Ⅱ～Ⅲ级),男17例、女3例,年龄37～74岁。其中心肌缺血14例,特发性充血性心肌病6例。除1例外均已用速尿(80～750mg/
Patients with severe congestive heart failure (CHF) often suddenly die of ventricular arrhythmias. However, most antiarrhythmic drugs have adverse reactions, especially negative inotropic effect, but can not be routinely used. The authors took a randomized controlled, parallel, double-blind study of changes in arrhythmias observed before and 12 weeks after treatment with Enalapril, an ACE inhibitor. The subjects were 20 chronic CHF (heart function Ⅱ ~ Ⅲ grade), 17 males and 3 females, aged 37 to 74 years. 14 cases of myocardial ischemia, idiopathic congestive cardiomyopathy in 6 cases. In addition to an exception have been furosemide (80 ~ 750mg /