1引言天冬甜素（Aspartame，APM）是目前世界上广泛应用的一种低热量、对人体无副作用的新型二肽甜味剂，其分子组成为a-L-天冬氨酰-L-苯丙氨酸甲酯．现行成熟的化学合成法是以苯丙氨酸甲酯（L-PheOMe）为原料，通过与L-天冬氨酸酐缩合产生。a-L-天冬氨酰-L-苯丙氨酸甲酯．本文 1 Introduction Aspartame (APM) is a new type of dipeptide sweetener with low calorie and no side effect on the human body. Its molecular composition is aL-aspartyl-L-phenylpropanal Methyl ester. The current mature chemical synthesis method is based on phenylalanine methyl ester (L-PheOMe) as raw material, by condensation with L-aspartic anhydride produced. a-L-aspartyl-L-phenylalanine methyl ester. This article