论文部分内容阅读
目的:研究外阴白色病变组织中微循环状况,探讨外阴白色病变的发病机制。方法:对来医院就诊的均于阴道镜下病变明显处取活组织病理检查,证实为外阴白色病患者41例,采用免疫组织化学方法检测在41例外阴白色病变(其中鳞状上皮增生22例,硬化性苔藓19例)组织中CD34的表达情况,8例正常的外阴组织做对照。结果:外阴硬化性苔藓的微血管数目(MVD值)显著低于正常外阴组,差异有统计学意义(P<0.05),外阴鳞状上皮增生与正常外阴组织相比差异无统计学意义(P>0.05),且硬化性苔藓(LS组)与鳞状上皮增生(SH组)之间存在显著性差异,硬化性苔藓MVD值低于鳞状上皮增生。结论:外阴硬化性苔藓组织中微血管数目减少明显,鳞状上皮增生中血管数目无明显改变。
Objective: To study the microcirculation in vulvar and white lesions and to explore the pathogenesis of white lesions in vulva. Methods: All the patients who came to the hospital were examined by biopsy under the colposcopy. 41 cases of vulvar white disease were confirmed, and 41 cases of vulvar white lesions (of which 22 cases were squamous hyperplasia , 19 cases of sclerosing moss) in the expression of CD34, 8 cases of normal vulva tissue as a control. Results: MVD of vulva vulgaris was significantly lower than that of normal vulva (P <0.05), while vulvar squamous hyperplasia had no significant difference compared with normal vulva (P> 0.05). There was also significant difference between sclerotic lichen (LS) and squamous hyperplasia (SH), and the value of MVD was lower than that of squamous hyperplasia. CONCLUSION: The number of microvessels in vulva vulgaris was significantly reduced, and the numbers of blood vessels in squamous hyperplasia had no significant changes.