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检测了７２例肾移植患者血中可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）、肿瘤坏死因子（ＴＮＦ）及白细胞介素６（ＩＬ－６）的水平。结果发现，正常健康对照组ＳＩＬ－２Ｒ为１２５±５４ｋＵ／Ｌ，术后肾功能平稳组为２５６±９３ｋＵ／Ｌ，环孢素Ａ中毒组为３３８±７３ｋＵ／Ｌ，而ＴＮＦ在这几组中均测不出，ＩＬ－６均小于５ｋＵ／Ｌ。肾移植术后ＳＩＬ－２Ｒ迅速下降，与血肌酐有明显的一致性，ＩＬ－６水平升高，第２天达高峰（１８．２５±２．３６ｋＵ／Ｌ），以后逐渐下降，１０天后降至５ｋＵ／Ｌ。发生急性排斥反应组ＳＩＬ－２Ｒ为１０７７±４４８ｋＵ／Ｌ，升高较血肌酐提早２．２天，敏感性达９４．４％，特异性达９１．７％；ＩＬ－６为５９．９±３５．２７ｋＵ／Ｌ，并较临床症状出现平均提早１．２天；ＴＮＦ为３３．６７±１３．７μｇ／Ｌ，检出率为６７％。感染组的ＳＩＬ－２Ｒ、ＩＬ－６、ＴＮＦ分别为１６２０±３９７ｋＵ／Ｌ、７９．７５±６１ｋＵ／Ｌ及１２７．５±８３．８μｇ／Ｌ。结果表明，ＳＩＬ－２Ｒ、ＴＮＦ、ＩＬ－６可作为监测肾移植排斥反应的指标。
The levels of soluble interleukin 2 receptor (SIL-2R), tumor necrosis factor (TNF) and interleukin 6 (IL-6) were measured in 72 renal transplant recipients. The results showed that SIL-2R was 125 ± 54kU / L in normal healthy control group, 256 ± 93kU / L in stable renal function group and 338 ± 73kU / L in cyclosporin A poisoning group, while TNF in these groups Can not be measured, IL-6 were less than 5kU / L. The SIL-2R level decreased rapidly after renal transplantation, and there was a clear coincidence with serum creatinine. The level of IL-6 increased and peaked on the second day (18.25 ± 2.36kU / L), then decreased gradually and dropped 10 days later To 5 kU / L. SIL-2R in acute rejection group was 1077 ± 448kU / L, which was earlier than serum creatinine by 2.2 days, with a sensitivity of 94.4% and a specificity of 91.7%; IL-6 was 59.9 ± 35.27kU / L, and the average clinical symptoms appeared earlier 1.2 days; TNF was 33.67 ± 13.7μg / L, the detection rate was 67%. SIL-2R, IL-6 and TNF in infected group were 1620 ± 397kU / L, 79.75 ± 61kU / L and 127.5 ± 83.8μg / L, respectively. The results show that SIL-2R, TNF, IL-6 can be used as indicators to monitor renal allograft rejection.