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目的探讨表皮生长因子受体(EGFR)表达、微血管密度(MVD)在判断胸腺瘤浸润、复发和转移及其预后分析中的临床意义。方法用免疫组织化学Envision法检测单克隆抗体EGFR、CD34在57例胸腺瘤患者中的表达,并结合53获随访患者的随访资料进行预后分析。结果 68%胸腺瘤呈EGFR过表达,EGFR过表达与组织学类型无关(P>0.05);浸润性胸腺瘤和复发/转移组EGFR过表达率分别高于包膜内胸腺瘤和非复发/转移组,差异均有统计学意义(均P<0.05)。MVD在胸腺瘤不同类型之间总体差异有高度统计学意义(P<0.01);浸润性胸腺瘤和复发/转移组MVD分别高于包膜内胸腺瘤和非复发/转移组,差异均有统计学意义(均P<0.05)。Kaplan-Meier生存曲线显示:EGFR过表达和高MVD患者5生存率和10年生存率均低于对照组,但差异无统计学意义(均P>0.05)。结论胸腺瘤显示EGFR过表达和活跃的肿瘤微血管生成,EGFR过表达和高MVD值有助于判断胸腺瘤的浸润、复发和转移,对评估患者的预后有一定参考价值。
Objective To investigate the clinical significance of the expression of epidermal growth factor receptor (EGFR) and microvessel density (MVD) in determining the invasion, recurrence and metastasis of thymoma and its prognosis. Methods Immunohistochemical Envision method was used to detect the expression of monoclonal antibody EGFR and CD34 in 57 patients with thymoma. The prognosis of 53 patients with follow-up were analyzed retrospectively. Results The overexpression of EGFR in 68% of thymoma showed no correlation with histological type (P> 0.05). The overexpression of EGFR in invasive thymoma and recurrent / metastatic group was higher than that in non-recurrent / metastatic Group, the differences were statistically significant (all P <0.05). The overall difference of MVD between different types of thymoma was statistically significant (P <0.01). The MVD of invasive thymoma and recurrent / metastatic group were higher than those of intratumoral thymomas and non-recurrence / metastasis Significance (both P <0.05). Kaplan-Meier survival curves showed that the 5-year survival rate and 10-year survival rate of patients with EGFR overexpression and high MVD were lower than those of the control group, but the difference was not statistically significant (all P> 0.05). Conclusion Thymoma shows that overexpression of EGFR and active tumor angiogenesis, overexpression of EGFR and high MVD value can be helpful in judging the infiltration, recurrence and metastasis of thymoma. It is of great value to evaluate the prognosis of patients.