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目的探讨大肠癌患者免疫功能与分期的关系。方法采用免疫荧光法和透射比浊法测定60例大肠癌患者和20例正常人的细胞免疫及体液免疫功能。结果大肠癌患者CD3+、CD4+、NK、C3、C4、IgG、IgA、IgM、CD4+/CD8+比值降低,CD8+高于正常对照组,这种变化随临床分期的增高更加显著(P<0.05)。结论大肠癌患者存在免疫功能抑制,随临床分期的增高而加重。测定大肠癌患者的免疫功能可以判断肿瘤发展情况与预后。根治性切除肿瘤,行免疫化疗是必要的。
Objective To investigate the relationship between immune function and staging in patients with colorectal cancer. Methods The immune and humoral immunity of 60 patients with colorectal cancer and 20 normal controls were detected by immunofluorescence and turbidimetry. Results The ratio of CD3 +, CD4 +, NK, C3, C4, IgG, IgA, IgM, CD4 + / CD8 + in colorectal cancer was lower than that in normal control group. The change was more significant with the clinical stage (P <0.05). Conclusion The immune function of patients with colorectal cancer is inhibited, which aggravates with the increase of clinical stage. Determination of immune function in patients with colorectal cancer can determine the tumor development and prognosis. Radical resection of the tumor, immunotherapy is necessary.