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在2006年Huanjie Yang等发现雷公藤红素可以诱导前列腺癌细胞凋亡及肿瘤坏死,是一种有效的天然蛋白酶抑制剂,自此引发了雷公藤红素抗癌作用及其机制的研究热潮。雷公藤红素可以通过多方面发挥其抗癌作用,包括抑制肿瘤细胞生长、阻滞细胞周期和诱导凋亡,抑制癌细胞蛋白酶,抑制信号通路,影响肿瘤相关蛋白、肿瘤坏死因子等,是一种潜在的天然抗肿瘤药物,对前列腺癌、肺癌、肝癌、白血病、胶质瘤、黑色素瘤、结肠癌、卵巢癌、乳腺癌等肿瘤细胞具有一定的抗肿瘤作用。然而由于其性质较为不稳定,而且存在毒性,为了拓宽雷公藤红素的临床应用,充分发挥其药理药效作用,采用药物制剂新技术降低雷公藤红素毒性,提高其溶解度是目前重要的研究方向之一。本文对2006年以来雷公藤红素及其制剂的抗肿瘤作用相关文献资料进行分析和综述,为今后雷公藤红素抗肿瘤新型制剂的研究提供参考。
In 2006, Huanjie Yang et al. Found that tripterine can induce apoptosis and tumor necrosis of prostate cancer cells, which is a potent natural protease inhibitor, which has led to the research crazily and its mechanism. Tripterine can exert its anti-cancer effect in many aspects, including inhibiting tumor cell growth, arresting cell cycle and inducing apoptosis, inhibiting cancer cell protease, inhibiting signal pathway, affecting tumor related protein and tumor necrosis factor, etc. Potential natural anti-tumor drugs, on prostate cancer, lung cancer, liver cancer, leukemia, glioma, melanoma, colon cancer, ovarian cancer, breast cancer and other tumor cells have a certain anti-tumor effect. However, due to its instability and toxicity, in order to broaden the clinical application of triptatine and give full play to its pharmacological and pharmacodynamic effects, it is an important research to use new pharmaceutical preparations to reduce the toxicity of triptolide and improve its solubility One of the directions. This article analyzes and summarizes the literature data about the anti-tumor effect of tripterine and its preparation since 2006, which will provide a reference for the future research on the new antitumor preparations of tripterine.