自六十年代中期以来,在实验性休克动物及休克病人的血浆中,发现一种能抑制心肌收缩的物质,称为“心肌抑制因子”(Myocardial Depressant Factor,MDF)。这一发现对理解休克的发病机制有一定意义。MDF的文献报导可分两类,一是与烧伤性休克有关的,一是以其它型式的休克(如出血性、内毒素性、肠缺血性等)为观察对象的。本文就这两个侧面的有关材料,作一综合介绍。 Since the mid-1960s, a substance that inhibits myocardial contractions has been found in the plasma of experimental shock animals and shock patients, known as Myocardial Depressant Factor (MDF). This finding is of some significance for understanding the pathogenesis of shock. MDF literature reports can be divided into two categories, one with burn shock, one with other types of shock (such as hemorrhagic, endotoxin, intestinal ischemia, etc.) for the observation of the object. This article on the two sides of the relevant materials for a comprehensive introduction.