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目的:探讨来曲唑联合二甲双胍治疗多囊卵巢综合征（PCOS）不孕症患者的临床疗效。方法:选取2019年1—12月在大连市妇幼保健院就诊的PCOS并胰岛素抵抗指数增高（>2.69）不孕症患者75例，按照随机数字表法分为对照组（38例）与试验组（37例），对照组采用来曲唑治疗，试验组采用来曲唑联合二甲双胍治疗。比较两组患者治疗前后空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗水平、排卵率、妊娠率以及体质量、体质量指数（BMI）的变化。结果:试验组治疗后FBG低于对照组，但差异无统计学意义（n P>0.05）。试验组治疗后FINS、HOMA模型胰岛素抵抗指数（HOMA-IR）、体质量及BMI均低于对照组[（13.66 ± 1.55）mU/L比（8.40 ± 2.31）mU/L、3.10 ± 0.58比1.91 ± 0.63、（60.70 ± 4.61）kg比（65.99 ± 4.79）kg、（22.59 ± 1.64）kg/mn 2比（24.40 ± 1.70）kg/mn 2]，差异有统计学意义（n P0.05). The levels of FINS, insulin resistance index (HOMA-IR), the body mass and the BMI in the experimental group were significantly lower than those in the control group [ (13.66 ± 1.55) mU/L vs. (8.40 ± 2.31) mU/L, 3.10 ± 0.58 vs. 1.91 ± 0.63, (60.70 ± 4.61) kg vs. (65.99 ± 4.79) kg, (22.59 ± 1.64) kg/mn 2 vs. (24.40 ± 1.70) kg/mn 2], there were significant differences (n P<0.05). The ovulation rate and the pregnancy rate in the experimental group were significantly higher than those in the control group [91.9% (34/37) vs. 68.4% (26/38) , 45.9% (17/37) vs. 21.1% (8/38) ], there were significant differences (n P<0.05).n Conclusions:The treatment of PCOS-associated infertility with letrozole combined with metformin could promote ovulation, and had positive effects in improving the pregnancy rate.