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目的 探讨联合检测血清、胸水中粒细胞-巨噬细胞集落刺激因子(GM-CSF)和癌胚抗原(CEA)对肺癌的诊断价值和临床意义。方法 利用放射免疫法检测32名健康人的血清及78名肺癌患者(其中腺癌28例,鳞癌27例,小细胞癌23例)血清和胸水中GM-CSF和CEA的含量。结果 肺癌各组血清GM-CSF均明显低于正常组,而各组之间血清与胸水的含量差异均无显著意义。血清中CEA含量各组均明显高于正常组,且腺癌组升高幅度最大,小细胞癌升高幅度最小,各组之间差异均有显著意义。胸水CEA含量各组变化与血清相似。血清和胸水GM-CSF的含量随临床症状的加重而逐渐降低。而CEA含量逐渐升高,相关性显著。结论 肺癌的病情严重程度不同,GM-CSF、CEA的含量也不同。检测GM-CSF、CEA对临床应用GM-CSF治疗肺癌具有指导作用。
Objective To investigate the diagnostic value and clinical significance of combined detection of GM-CSF and CEA in lung cancer. Methods The levels of GM-CSF and CEA in serum and pleural effusion of 32 healthy people and 78 lung cancer patients (including 28 adenocarcinoma, 27 squamous cell carcinoma and 23 small cell carcinoma) were detected by radioimmunoassay. Results The serum levels of GM-CSF in each group were significantly lower than those in normal group, while there was no significant difference in serum and pleural effusion between groups. Serum CEA levels in each group were significantly higher than the normal group, and the highest increase in adenocarcinoma group, the smallest increase in small cell carcinoma, the differences between the groups were significant. CEA content in pleural effusion and serum changes in each group similar. Serum and pleural effusion GM-CSF levels gradually decreased with the clinical symptoms. The CEA content gradually increased, the correlation was significant. Conclusion The severity of lung cancer is different, and the contents of GM-CSF and CEA are also different. The detection of GM-CSF and CEA can guide the clinical application of GM-CSF in the treatment of lung cancer.