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应用免疫组化检测68例肝细胞癌（HCC）及其癌旁肝组织中nm23－H1蛋白和c－erbB－2蛋白的表达。结果显示nm23－H1蛋白在癌旁肝组织中均呈强阳性表达，肝细胞癌组织中38／68（56％）例呈阳性表达。阳性产物主要定位于肿瘤细胞胞浆，nm23－H1蛋白表达与HCC肿瘤体积、组织病理学分型及分级无关，而与肝内或肝外转移呈负相关。结果表明nm23-H1在抑制HCC肝内或肝外转移中起着重要作用。有可能成为评价HCC病人预后的一项指标。
Immunohistochemistry was used to detect the expression of nm23-H1 protein and c-erbB-2 protein in 68 cases of hepatocellular carcinoma (HCC) and its adjacent liver tissues. The results showed that nm23-H1 protein was strongly expressed in para-carcinoma liver tissue, and 38/68 (56%) cases of hepatocellular carcinoma were positively expressed. The positive products were mainly located in the cytoplasm of tumor cells. The expression of nm23-H1 protein was not related to tumor volume, histopathological type and grade of HCC, but negatively related to intrahepatic or extrahepatic metastasis. The results indicate that nm23-H1 plays an important role in inhibiting intrahepatic or extrahepatic metastasis of HCC. It may be an indicator to evaluate the prognosis of HCC patients.