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目的:探讨参芪扶正注射液联合NP方案在非小细胞肺癌术后辅助化疗中的临床应用。方法:选取90例Ⅱ期非小细胞肺癌根治术后患者,随机分为治疗组45例、对照组45例。对照组给予NP方案术后辅助化疗:长春瑞滨(25mg/m2 d1、8)+顺铂(25mg/m2 d1~d3),每21天为1个疗程,共4个疗程。治疗组在NP方案化疗基础上加用参芪扶正注射液。评价两组的临床疗效,观察两组患者治疗前后生活质量,改善乏力、纳差症状,减少化疗引起的骨髓抑制(白细胞、血小板计数、血红蛋白)和胃肠道反应的发生率。结果:两组患者经治疗后,治疗组患者总有效率为75.56%,显著高于对照组的45.67%;治疗组患者的生活质量改善率为95.55%,显著高于对照的73.34%;对照组患者不良反应发生率为37.78%,明显高于治疗组的17.78%,差异具有统计学意义(P<0.05)。结论:参芪扶正注射液联合NP方案在非小细胞肺癌术后辅助化疗中可以改善乏力、纳差症状,减少化疗引起的骨髓抑制(白细胞、血小板计数、血红蛋白)和胃肠道反应的发生率。参芪扶正注射液联合长春瑞滨+顺铂(NP)方案的有效率高于单用NP方案组。
Objective: To investigate the clinical application of Shenqi Fuzheng injection combined with NP regimen in postoperative adjuvant chemotherapy for non-small cell lung cancer. Methods: 90 patients with stage Ⅱ non-small cell lung cancer after radical surgery were randomly divided into treatment group (n = 45) and control group (n = 45). The control group received NP regimen adjuvant chemotherapy: vinorelbine (25mg / m2 d1,8) + cisplatin (25mg / m2 d1 ~ d3), every 21 days for a course of treatment, a total of 4 courses. The treatment group was given Shenqi Fuzheng Injection on the basis of NP chemotherapy. The clinical efficacy of both groups was evaluated. The quality of life before and after treatment in both groups was observed, and the symptoms of fatigue and anorexia were improved and the incidence of bone marrow suppression (leucocyte, platelet count, hemoglobin) and gastrointestinal reaction caused by chemotherapy were decreased. Results: After treatment, the total effective rate was 75.56% in the treatment group and 45.67% in the control group. The improvement rate of the quality of life in the treatment group was 95.55%, which was significantly higher than that in the control group (73.34%). The control group The incidence of adverse reactions in patients was 37.78%, significantly higher than 17.78% in the treatment group, the difference was statistically significant (P <0.05). Conclusion: Shenqi Fuzheng injection combined with NP regimen in postoperative adjuvant chemotherapy for non-small cell lung cancer can improve symptoms of fatigue and anorexia and reduce the incidence of chemotherapy induced bone marrow suppression (white blood cells, platelet count, hemoglobin) and gastrointestinal reactions . Shenqi Fuzheng injection combined with vinorelbine + cisplatin (NP) regimen was more effective than the single NP regimen.