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目的了解山东省寿光市HBsAg阳性者乙肝病毒血清标志物(HBVm)组合模式,以及e抗原阳性者年龄、性别分布。方法用酶联免疫吸附法(ELISA)检测居民体检时发现的HBsAg阳性者的HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc。结果共检出HBsAg阳性4312例,男性2554例、占59.2%,女性1758例、占40.8%;患者年龄3~91岁,平均35.9岁;HBVm有13种组合模式,HBsAg阳性、抗-HBe阳性或阴性、抗-HBc阳性占73.47%;HBeAg阳性率24.65%,男性高于女性,随年龄增加阳性率降低,年均递减0.89%;抗-HBe阳性率56.40%,女性高于男性,随年龄增长阳性率增高,年均递增0.92%。结论HBsAg阳性者以HBeAg阴性为主,随年龄增长HBeAg阳性率逐渐降低;小年龄组人群HBeAg、抗-HBe血清学转换率高,40岁以上人群转换率减慢。
Objective To understand the combined pattern of HBsAg positive hepatitis B virus (HBVm) markers and the age and gender distribution of e antigen in Shouguang City, Shandong Province. Methods HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were detected by enzyme linked immunosorbent assay (ELISA). Results A total of 4312 HBsAg positive cases were found, including 2554 males (59.2%) and 1758 females (40.8%). The patients were from 3 to 91 years old with an average of 35.9 years old. There were 13 combinations of HBsAg, HBsAg positive and anti-HBe positive Or negative, anti-HBc positive accounted for 73.47%; HBeAg positive rate was 24.65%, male than female, with the increase of age, the positive rate decreased with an average annual decrease of 0.89%; anti -HBe positive rate of 56.40%, women than men, with age The positive rate of growth increased with an average annual increase of 0.92%. Conclusions HBeAg-positive patients are mainly HBeAg-negative, and the positive rate of HBeAg gradually decreases with age. The seroconversion rate of HBeAg and anti-HBe in children with small age group is high, and the conversion rate of people over 40 years old is slowed down.