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目的 :探讨托烷司琼及甲氧氯普胺两药在预防顺铂化疗所引起的不良反应的疗效。方法 :将 16 7例病人分为托烷司琼及甲氧氯普胺二组 ,在顺铂联合化疗时应用 ,观察两药对化疗副反应恶心呕吐的控制情况。结果 :托烷司琼对预防化疗引起的恶心呕吐的疗效明显高于甲氧氯普胺 ,结果有统计学意义 (P <0 .0 1)。结论 :托烷司琼能够有效的预防顺铂所引起的明显恶心、呕吐的副反应 ,使用简单方便 ,且无明显毒副作用 ,值得进一步推广使用。
Objective: To investigate the efficacy of tropisetron and metoclopramide in the prevention of adverse reactions caused by cisplatin chemotherapy. Methods: Totally 167 patients were divided into two groups: tropisetron and metoclopramide. When cisplatin combined with chemotherapy, the two drugs were used to control the side effects of chemotherapy and nausea and vomiting. Results: The effect of tropisetron on the prevention of chemotherapy-induced nausea and vomiting was significantly higher than that of metoclopramide. The results were statistically significant (P <0.01). Conclusion: Tropisetron can effectively prevent cisplatin-induced nausea and vomiting caused by side effects, easy to use, and no significant side effects, it is worth further promotion.