NF_1是一种主要影响神经组织细胞生长的遗传病,呈常染色体显性遗传,发病率约1/4 000。NF_1的诊断按统一标准,即6个以上的大于6毫米的牛奶咖啡斑,2个以上的NF,腋窝雀斑、视神经胶质瘤,2个以上的Lisch结和骨发育不良。本病生化缺陷迄今未知,推测其与神经嵴分化有关。近年发现,NF_1基因是定位于人类17号染色体的近着丝粒区。为进一步定位NF_1基因,作者利 NF_1 is a genetic disease that mainly affects the growth of nerve tissue cells and is autosomal dominant with an incidence of about 1/4 000. NF_1 was diagnosed on a uniform basis by more than six milk coffee stains greater than 6 millimeters, more than two NFs, axillary freckles, optic gliomas, more than two Lisch knots and osteodysplasia. Biochemical deficiencies of the disease so far unknown, speculated that it is related to neural crest differentiation. In recent years, it has been found that the NF_1 gene is located near the centromere of human chromosome 17. To further locate the NF_1 gene, the authors Lee